灌注系統(tǒng)概述
HSE—HA生理學(xué)系統(tǒng)是一系列應(yīng)用廣泛的完備產(chǎn)品，可用于整體動(dòng)物生理學(xué)、立體或在體器官和組織灌注及組織浴槽研究。這些系統(tǒng)具有廣泛的應(yīng)用，包括傳統(tǒng)的**藥理學(xué)、DMPK、毒理學(xué)、呼吸系統(tǒng)、心臟病學(xué)、分子生物學(xué)和生理學(xué)。每個(gè)系統(tǒng)都設(shè)計(jì)了標(biāo)準(zhǔn)的組件，再加一些其他配置以適合特殊研究的需要。。標(biāo)注組件也意味著如果你是需要將現(xiàn)有設(shè)備配齊，或者進(jìn)行系統(tǒng)升級(jí)，或者是完整的配套產(chǎn)品，你都只需要購買需要的構(gòu)件。HSE-HA生理學(xué)系統(tǒng)為你提供各種工具，使你的研究走向多產(chǎn)和成功。
我們提供大多數(shù)生理學(xué)檢測(cè)設(shè)備，包括放大器、電極、傳感器和電化學(xué)檢測(cè)器。參數(shù)包括力、位移、壓力、液體和氣體流、心電圖（單導(dǎo)聯(lián)—12導(dǎo)聯(lián)系統(tǒng)）、MAP（單個(gè)或多個(gè)部位）、腦電圖、肌電圖、連續(xù)支流灌注傳統(tǒng)的血?dú)鈪?shù)和電解質(zhì)的分析，可以選擇程序化軟件和傳統(tǒng)的刺激器作為放大器、電極和傳感器等產(chǎn)品的補(bǔ)充。
HSE-DAQ系統(tǒng)產(chǎn)品家族（BDAS、ACAD、HAEMODYN、ISOHEART、PULMODYN、PENNOCK）可以記錄你的初始信號(hào)，計(jì)算到處的參數(shù)，注釋數(shù)據(jù)，快速簡(jiǎn)易的輸入確定的數(shù)據(jù)用于分析。同時(shí)還可以選擇用于進(jìn)一步分析的軟件模塊，帶狀記錄紙打印，自動(dòng)和控制模塊等。產(chǎn)品經(jīng)過預(yù)先設(shè)置，打開包裝即可使用，并專門設(shè)計(jì)符合你的系統(tǒng)配置和數(shù)據(jù)分析要求。
• For investigating the tone of small blood vessels under the effect of vasoactive substances
• Compact arrangement
• Organ is in warm and moist environment during perfusion
• Electrical field stimulation capabilities
The rat hind leg and the rabbit ear are conventional preparations for investigating the tone of blood vessels under the effect of vasoactive substances in the peripheral vascular bed, either at constant perfusion pressure or at constant flow. Both set-ups suffer from the disadvantage that the measurement is affected by early edema formation. In the rat, the mesenteric circulation receives approximately 20% of the cardiac output; its regulation may therefore contribute significantly to the systemic blood pressure and circulating blood volume. The presence of arterioles, i.e. the most important vessels in the regulation of vascular resistance, renders the mesenteric bed an important preparation for the study of vascular physiology, pathophysiology and pharmacology.
The organ bath for the rat mesenteric bed consists of a moist chamber with cover, both water jacketed. The mesenteric tissue is placed into the moist chamber on a stainless steel mesh which also acts as anode during
electrical stimulation. The superior mesenteric artery is cannulated (steel cannula) and perfused at constant flow (e.g. 5 ml/min) through a roller pump via a heat exchanger included in the moist chamber. The test drug is introduced through a separate roller pump or a syringe pump directly before the vascular bed preparation. The perfusion pressure is measured in a branch before the stainless steel cannula. For electrical stimulation, the Mesenteric Bed is placed on a stainless steel grid and a metal clip is attached to the aorta section near the steel cannula.
References:
1) Cusma-Pelogia, N. et al.: Endothelium Inactivation in In Vitro Perfused Vascular Beds - Comparison of Methods. J. Pharmacol and Toxicol. Methods 29, 157-163 (1993)
2)