灌注系統(tǒng)概述
HSE—HA生理學(xué)系統(tǒng)是一系列應(yīng)用廣泛的完備產(chǎn)品，可用于整體動物生理學(xué)、立體或在體器官和組織灌注及組織浴槽研究。這些系統(tǒng)具有廣泛的應(yīng)用，包括傳統(tǒng)的**藥理學(xué)、DMPK、毒理學(xué)、呼吸系統(tǒng)、心臟病學(xué)、分子生物學(xué)和生理學(xué)。每個系統(tǒng)都設(shè)計了標(biāo)準(zhǔn)的組件，再加一些其他配置以適合特殊研究的需要。。標(biāo)注組件也意味著如果你是需要將現(xiàn)有設(shè)備配齊，或者進(jìn)行系統(tǒng)升級，或者是完整的配套產(chǎn)品，你都只需要購買需要的構(gòu)件。HSE-HA生理學(xué)系統(tǒng)為你提供各種工具，使你的研究走向多產(chǎn)和成功。
我們提供大多數(shù)生理學(xué)檢測設(shè)備，包括放大器、電極、傳感器和電化學(xué)檢測器。參數(shù)包括力、位移、壓力、液體和氣體流、心電圖（單導(dǎo)聯(lián)—12導(dǎo)聯(lián)系統(tǒng)）、MAP（單個或多個部位）、腦電圖、肌電圖、連續(xù)支流灌注傳統(tǒng)的血氣參數(shù)和電解質(zhì)的分析，可以選擇程序化軟件和傳統(tǒng)的刺激器作為放大器、電極和傳感器等產(chǎn)品的補充。
HSE-DAQ系統(tǒng)產(chǎn)品家族（BDAS、ACAD、HAEMODYN、ISOHEART、PULMODYN、PENNOCK）可以記錄你的初始信號，計算到處的參數(shù)，注釋數(shù)據(jù)，快速簡易的輸入確定的數(shù)據(jù)用于分析。同時還可以選擇用于進(jìn)一步分析的軟件模塊，帶狀記錄紙打印，自動和控制模塊等。產(chǎn)品經(jīng)過預(yù)先設(shè)置，打開包裝即可使用，并專門設(shè)計符合你的系統(tǒng)配置和數(shù)據(jù)分析要求。
• Constant pressure or constant flow perfusion of isolated rodent hearts with the same apparatus
• Compact unit improved for low volume and high temperature stability
• High perfusion pressure possible (up to 300 mmHg)
• Continuous measurement of heart mechanics and bioelectrical signals
• Langendorff or Working Heart Configurations – Easy to Upgrade
• The special flow resistance and compliance chamber closely mimics the in-vivo afterload
• Applications:
– Testing inotropic and vasoactive substances
– Testing cardiac rhythm (chronotropic and arrythmogenic effects)
– Assessment of the refractory period
– Cardiovascular screening of transgenic mice
The IH-SR apparatus has been designed for experiments on the isolated heart of small rodents like rats or guinea pigs, and especially mice. Available in two versions: LH = Langendorff Heart and WH = Working Heart. Both versions allow easy conversion between constant pressure and constant flow conditions. The WH version of the apparatus allows isolated heart experiments in both LH or WH mode. Mode changeover is performed through a few simple manipulations; no additional conversion of the apparatus required. The precision design simplifies system use and minimizes user error.
In LH mode, the coronary vessels are perfused by retrograde flow through the aorta. Under constant pressure conditions, coronary flow can be measured with a flow probe while in constant flow experiments, the perfusion pressure can be measured with a pressure transducer. Measurement of isovolumetirc left ventricular pressure (LVP) (balloon method) is facilitated by custom LVP balloon catheters.
In WH mode the left atrium is cannulated and the heart performs pressure-volume work. Atrial preload is set by a simple fluid column height adjustment. Measurable parameters in WH mode include perfusion pressure, aortic flow, total cardiac output from left atrial flow, atrial preload pressure, LVP pressure via aortic cannulation or ventricular cannulation.
Parameters that can be monitored in either LH or WH modes include ECG, and Monophasic Action Potential. Traditional blood gas measurements (pO2, pCO2 and pH) as well as ion concentrations can also be monitored by pulmonary artery cannulation in rats and guinea pigs but is not available for mice.
• Constant pressure or constant flow perfusion of isolated rodent hearts with the same apparatus
• Compact unit improved for low volume and high temperature stability
• High perfusion pressure possible (up to 300 mmHg)
• Continuous measurement of heart mechanics and bioelectrical signals
• Langendorff or Working Heart Configurations – Easy to Upgrade
• The special flow resistance and compliance chamber closely mimics the in-vivo afterload
• Applications:
– Testing inotropic and vasoactive substances
– Testing cardiac rhythm (chronotropic and arrythmogenic effects)
– Assessment of the refractory period
– Cardiovascular screening of transgenic mice